Schedule

Sunday, October 6th

07.00

Registration

08.30

 

Welcome & Opening Remarks

OTS President: Masad Damha, PhD, McGill University

08.45-10.30

 

Session I: Aptamers: Mechanisms & Applications

Chair: Bruce Sullenger, PhD, Duke University Medical Center

08.45-09.15

 

New Modes of Folding and Binding in Nucleic Acid Ligands with Enhanced Chemical Diversity — Implications for Development of Diagnostics and Therapeutics

Nebojsa Janjic, PhD, SomaLogic, Inc.

09.15-09.45

MCP-1 Inhibitor NOX-E36. The long way from in vitro selection to clinical data
Sven Klussmann, PhD, NOXXON Pharma AG

09.45-10.15

Forward and Reverse Translation with Antithrombotic Aptamers and their Antidotes
Bruce Sullenger, PhD, Duke University Medical Center

10.15-10.30

Streamlined RNA Aptamer Selection with Microcolumn Devices and RAPID Method, and Identification with High-throughput RNA Interaction Assay
Abdullah Ozer, PhD, Cornell University

10.30-11.00

Refreshment Break

11.00-13.00

Session II: Immunomodulatory Oligonucleotides

Chair: Gunther Hartmann, MD, PhD, University Hospital Bonn, Germany

11.00-11.30

 

A Cyclic Di-nucleotide Signaling Pathway Mediates Innate Immune Responses to Cytosolic DNA in Mammalian Cells

Lijun Sun, PhD, UT Southwestern Medical Center

11.30-12.00

Structure-Function Studies of Cytosolic DNA Sensors Governing the Interferon Response
Dinshaw J. Patel, PhD, Memorial Sloan-Kettering Cancer Center

12.00-12.30

Nucleotide Starvation: a SAMHD1-dependent Strategy for Cell-intrinsic Anti-retroviral Defense
Jan Rehwinkel, PhD, University of Oxford

12.30-12.45

RNAdjuvant®: A Novel, Highly-potent, RNA-based Adjuvant for Prophylactic and Therapeutic Vaccines

Karl-Josef Kallen, MD, PhD, CureVac GmbH

12.45-13.00

cGAS Produces a 2’-5’-linked Cyclic Dinucleotide Second Messenger that Activates STING

Marion Goldeck, MSc, University Hospital Bonn, Germany

13.00-14.00

Lunch Break

 

 

14.00-16.00

Session III: Promoting RNA Degradation I
Chair: Muthiah Manoharan, PhD, Alnylam Pharmaceuticals

14.00-14.30

RNAi in Cell Nuclei
David Corey, PhD, UT Southwestern Medical Center

14.30-15.00

The Therapeutic Potential of Tricyclo-DNA
Christian Leumann, PhD, University of Bern

15.00-15.30

Assembly of the Catalytic Engine of RNAi, a RISCy Business
Qinghua Liu, PhD, UT Southwestern Medical Center

15.30-15.45

Atu027 Plus Gemcitabine in Advanced or Metastatic Pancreatic Cancer (Atu027-I-02)
Klaus Giese, PhD, Silence Therapeutics AG

15.45-16.00

Peptide-Conjugated Glucan Particles for Delivery of Therapeutic siRNA
Jessica L. Cohen, PhD, University of Massachusetts Medical School

16.00-16.30

Refreshment Break

16.30-17.30

Keynote Presentation I

Sequence-defined Carriers for Targeted Nucleic Acid Delivery
Ernst Wagner, PhD, Ludwig-Maximilians University (LMU) of Munich

Moderator: Mike Gait, PhD, MRC Laboratory

17.30-19.30

Welcome Reception and Poster Session I

ODD numbered posters hosted